Alan T Nurden Selected Research

Thrombasthenia (Glanzmann Thrombasthenia)

12/2019	A Glanzmann thrombasthenia family associated with a TUBB1-related macrothrombocytopenia.
1/2019	Acquired Glanzmann thrombasthenia: From antibodies to anti-platelet drugs.
5/2018	Acquired Antibodies to αIIbβ3 in Glanzmann Thrombasthenia: From Transfusion and Pregnancy to Bone Marrow Transplants and Beyond.
1/2018	In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.
1/2017	Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?
5/2015	Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort.
6/2014	Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets.
10/2013	Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.
9/2013	Glanzmann thrombasthenia: state of the art and future directions.
1/2013	A novel amino acid substitution of integrin αIIb in Glanzmann thrombasthenia confirms that the N-terminal region of the receptor plays a role in maintaining β-propeller structure.

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Alan T Nurden Research Topics

Disease

18	Thrombasthenia (Glanzmann Thrombasthenia) 12/2019 - 03/2002
17	Hemorrhage 01/2021 - 10/2002
9	Thrombosis (Thrombus) 11/2018 - 04/2002
5	Inflammation (Inflammations) 01/2019 - 02/2013
4	Bernard-Soulier Syndrome (Giant Platelet Syndrome) 07/2014 - 02/2008
3	Neoplasms (Cancer) 01/2020 - 01/2016
3	Atherosclerosis 07/2017 - 12/2006
2	Neoplasm Metastasis (Metastasis) 01/2020 - 01/2016
2	Leukemia 01/2019 - 11/2018
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2019 - 01/2005
2	Thrombocytopenia (Thrombopenia) 01/2017 - 10/2004
2	Rare Diseases (Rare Disease) 02/2013 - 07/2008
2	Gray Platelet Syndrome 07/2009 - 07/2004
2	Skin Ulcer 05/2008 - 01/2004
2	Type 2 von Willebrand Disease 10/2006 - 09/2006
1	Thromboinflammation 12/2021
1	Scott Syndrome 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019
1	Burns 01/2019
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Ulcer 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Venous Thrombosis (Deep-Vein Thrombosis) 05/2018
1	Neonatal Alloimmune Thrombocytopenia 05/2018
1	Epistaxis (Nosebleed) 01/2018
1	Infections 01/2018
1	Factor XIII Deficiency 10/2013
1	Brain Ischemia (Cerebral Ischemia) 07/2013
1	Brain Infarction 07/2013
1	Vascular System Injuries 01/2013
1	Hemophilia A (Haemophilia) 01/2013
1	Ischemic Stroke 01/2013
1	Hemorrhagic Disorders (Hemorrhagic Diathesis) 09/2011
1	Type 3 von Willebrand Disease 11/2009
1	Systemic Scleroderma (Systemic Sclerosis) 09/2009
1	Fibrosis (Cirrhosis) 03/2007
1	Primary Myelofibrosis (Myelosclerosis) 01/2007
1	Atherosclerotic Plaque (Atheroma) 12/2006
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2005
1	Unstable Angina 05/2003
1	Myocardial Ischemia (Ischemic Heart Diseases) 02/2003

Drug/Important Bio-Agent (IBA)

13	IntegrinsIBA 01/2021 - 05/2003
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2005
5	Platelet Glycoprotein GPIIb-IIIa ComplexIBA 02/2008 - 03/2002
4	AntibodiesIBA 01/2019 - 10/2004
4	FibrinIBA 01/2019 - 10/2013
4	von Willebrand FactorIBA 11/2009 - 09/2006
3	Pharmaceutical PreparationsIBA 01/2019 - 10/2004
3	CollagenIBA 11/2018 - 04/2002
3	recombinant FVIIa (rFVIIa)FDA Link 05/2018 - 07/2017
3	PhosphatidylserinesIBA 06/2014 - 08/2010
3	Fibrinogen (Factor I)FDA Link 10/2013 - 09/2002
3	Glycoproteins (Glycoprotein)IBA 07/2008 - 07/2004
2	Collagen ReceptorsIBA 01/2021 - 07/2004
2	EphrinsIBA 01/2021 - 11/2018
2	platelet membrane glycoprotein VIIBA 01/2020 - 07/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 01/2007
2	Inosine Triphosphate (ITP)IBA 01/2019 - 01/2005
2	Thrombin FDA Link 05/2018 - 11/2005
2	CalciumIBA 07/2017 - 10/2012
2	Integrin alphaVbeta3IBA 09/2013 - 10/2012
2	CoagulantsIBA 07/2013 - 01/2013
2	Membrane Glycoproteins (Membrane Glycoprotein)IBA 02/2013 - 07/2008
2	Abciximab (ReoPro)FDA Link 10/2004 - 05/2003
2	Purinergic P2 Receptors (ADP Receptor)IBA 02/2003 - 04/2002
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	Ion Channels (Ion Channel)IBA 01/2021
1	Galectin 3 (LGALS3)IBA 01/2020
1	Biological ProductsIBA 01/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2018
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2018
1	LigandsIBA 11/2018
1	convulxinIBA 11/2018
1	DiglyceridesIBA 07/2017
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 07/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	CarbohydratesIBA 07/2014
1	estropipate (Ogen)FDA LinkGeneric 10/2013
1	TransglutaminasesIBA 10/2013
1	Factor VIII (Coagulation Factor VIII)IBA 01/2013
1	RNA Splice SitesIBA 09/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2009
1	Dental Implants (Dental Implant)IBA 05/2008
1	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 02/2008
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2007
1	CytokinesIBA 01/2007
1	Single-Chain AntibodiesIBA 12/2006
1	Nonsense Codon (Nonsense Mutation)IBA 02/2004
1	Tyr sulfate(1)- enkephalinamide-Leu (LETS)IBA 01/2004
1	Immunoglobulin Fab FragmentsIBA 05/2003

Therapy/Procedure

6	Therapeutics 12/2021 - 05/2003
2	Platelet Transfusion (Blood Platelet Transfusions) 01/2018 - 07/2017
1	Organ Transplantation 01/2019
1	Immunomodulation 01/2019
1	Catheters 05/2018
1	Transplantation 01/2013